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p62SQSTM1 is a scaffolding protein that interacts with various signaling molecules such as TRAF6, RIP, and aPKC p62 contains an LC3-interacting region and

The structural basis for ubiquitin recognition by the UBA domain of p62 has been investigated using NMR and reveals a novel binding mechanism  p62 and ubiquitinated substrates spontaneously coalesce into larger clusters, which result from the crosslinking of p62 filaments by the substrates

โค้ดneko New evidence supports an autophagy-independent key role of the adaptor p62 in signaling functions central to tumor initiation  New evidence supports an autophagy-independent key role of the adaptor p62 in signaling functions central to tumor initiation